Effects of the controlled temperature in the production of high-shear granulated protein-containing granules

During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, during high-shear granulation impeller chopper speeds induce temperatures influence parameters of products. In our work, we therefore aimed investigate effect cooling process on product by factorial design in accordance with QbD guidelines. Our other goal was study type two series were used prepare granules a granulator, water binder solution as granulating fluid, at different application design. The particle size higher when case prepared solution. pepsin had good effect, displayed larger size, breaking hardness favourable deformation process.